Name | 3-Amino-4-methylpyridine |
Synonyms | 3-AMINO-4-PICOLINE IFLAB-BB F1957-0029 4-METHYLPYRIDIN-3-AMINE 4-METHYL-3-PYRIDINAMINE 3-Amino-4-methylpyridine 3-AMINO-4-METHYLPYRIDINE 3-Amino-4-methyl pyridine 3-Pyridinamine, 4-methyl- 4-METHYL-PYRIDIN-3-YLAMINE |
CAS | 3430-27-1 |
EINECS | 608-968-1 |
InChI | InChI=1/C6H8N2/c1-5-2-3-8-4-6(5)7/h2-4H,7H2,1H3 |
Molecular Formula | C6H8N2 |
Molar Mass | 108.14 |
Density | 1.0275 (estimate) |
Melting Point | 102-107 °C |
Boling Point | 254°C |
Flash Point | 254°C |
Solubility | Soluble in Chloroform, Ethyl Acetate and Methanol. |
Vapor Presure | 0.0116mmHg at 25°C |
Appearance | Crystalline powder |
Color | White to Brown |
BRN | 107792 |
pKa | 6.83±0.18(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Sensitive | Hygroscopic |
Refractive Index | 1.5560 (estimate) |
MDL | MFCD00128871 |
Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
UN IDs | 2811 |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Note | Toxic |
Hazard Class | 6.1 |
Packing Group | III |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
application | 3-amino -4-methylpyridine is an important pharmaceutical and chemical intermediate, which is widely used in the synthesis and development of medicines, pesticides, and veterinary drugs. It has high application value and market value. |
preparation | 57g(0.4mol) of 2-chloro -3-amino -4-methylpyridine, 33g(0.4mol) of sodium acetate, 400mL of methanol, 0.95g of 5% palladium carbon (water content 54.13%), air in the autoclave and high-purity hydrogen aerating autoclave at a pressure of 0.4MPa, heating and stirring, the temperature is controlled at 60 ℃, the reaction is 8h, when the pressure is less than 0.15MPa, hydrogen needs to be supplemented. After the reaction is completed, cool to room temperature, open the kettle, and filter to obtain gray solid, recover palladium and carbon, dissolve the filtrate under reduced pressure, add 100mL of water to dissolve, and show orange yellow color or light yellow green liquid, adjust the pH value of the solution with 30% potassium hydroxide solution to be alkaline, extract with organic solvent, combine organic phase, dry with anhydrous magnesium sulfate, filter, dedissolve under reduced pressure, 41.1g of light yellow solid 3-amino -4-methylpyridine was obtained with 97.6% yield and 99.1% purity. |